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KMID : 0191119990140030319
Journal of Korean Medical Science
1999 Volume.14 No. 3 p.319 ~ p.322
Rheumatoid arthritis associated with myelodysplastic syndrome: a case report
Nam EJ
Kang YM/Kang HR/Kim JH/Rho HJ/Lee MK/Hyun SH/Kim GW/Lee JM/Kim NS
Abstract
Myelodysplastic syndromes (MDS) are a group of refractory anemias resulting from a clonal stem cell disorder often associated with cytogenetic abnormalities. There is increasing recognition of immunological abnormalities in patients with MDS, including defective B- and T-cell function, hyper- or hypogammaglobulinemia and monoclonal gammopathy. MDS have been associated with Sjogren's syndrome, polymyalgia rheumatica, relapsing polychondritis and systemic lupus erythematosus. Although there may be various rheumatologic features, including acute arthritis in MDS, chronic inflammatory arthritis is uncommonly combined. There have been a few reports that described cases of rheumatoid arthritis (RA) concurrent with MDS, but advanced rheumatoid arthritis with typical joint deformities has rarely been reported. We report a case of rheumatoid arthritis with atlantoaxial subluxation combined with refractory anemia in a 31-year-old woman.
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